This study sets out to investigate and document endangered local drug terminologies in Igbo southeast Nigeria. Nigeria, a multilingual country in Africa has copious local drug terminologies going into extinct, for which hardly any proper investigation and documentation exist on such disappearing linguistic terms especially in Igbo, southeast Nigeria. It is disheartening that the Igbo language spoken in South-Eastern Nigeria is endangered with increasingly reduced number of local drug terms. Currently, the dearth of knowledge and documentation of endangered local drug terminologies in Nigeria are at the peak of the lots of language endangerment, as well as health and socioeconomic challenges but have hitherto been neglected by earlier researchers. The need for the documentation of local drug terminologies manifest itself these times of serious language endangerment, as well as health and socioeconomic crisis informed mostly by COVID19. Investigating and documenting such vital terminologies is imperative in Nigeria’s competitive advantage in the global space for cultural, health (as well as COVID-19 interventions), preservation, and dissemination of Nigeria local languages. In this, we intend to: (i) list the local drug terminologies and the transcription, (ii) point the ones reported to have potentials of curing COVID-19 infections, (iii) the etymology, botanical, and the English names, and (iv) show the sentence examples. The data was collected using in-depth oral interview, group discussion, participant observation, surreptitious recording, and analysed descriptively. The study is useful to the teaching and learning of language documentation.